منابع مشابه
Circulating macroglobulinemia cells.
hepatosplenomegaly. The erythrocyte sedimentation rate was 184 mm/h. The hemoglobin was 8.5 g/dl, the leukocyte count was 3,500/mm with normal differential, and the platelet count was 181,000/mm. The bone marrow was hyperplastic and contained 60.2% of lymphoplasmacytoid cells. There was marked rouleaux formation of the erythrocytes. The serum protein was 10.6 g/dl with IgM 8,660 mg/dl, IgG 930 ...
متن کاملRare Circulating Cells in Familial Waldenström Macroglobulinemia Displaying the MYD88 L265P Mutation Are Enriched by Epstein-Barr Virus Immortalization
The MYD88 L265P is a recurrent somatic mutation in neoplastic cells from patients with Waldenström Macroglobulinemia (WM). We identified the MYD88 L265P mutation in three individuals from unrelated families, but its presence did not explain the disease segregation within these WM pedigrees. We observed the mutation in these three individuals at high allele fractions in DNA extracted from EBV-im...
متن کاملMacroglobulinemia
The monomers obtained by treating gamma(1)-macroglobulins with mercaptoethanol have proved to be antigenically different from normal 7S 7gamma-globulin. The depolymerization of the macroglobulins resulted in the loss of several antigenic determinants, although the monomers still cross-reacted with antisera against macroglobulins. Reaggregation of the monomers occasionally resulted in the recons...
متن کاملIn Waldenstrom's macroglobulinemia the quantity of detectable circulating monoclonal B lymphocytes correlates with clinical course.
Using a sensitive flow-cytometer-based method of detecting small numbers of morphologically normal monoclonal B lymphocytes, we have investigated the presence and quantity of these cells in the blood of 12 patients with Waldenstrom's macroglobulinemia. All 12 patients, including 6 at the time of asymptomatic presentation, had such circulating monoclonal cells. By comparison, 2 of 7 patients wit...
متن کاملWaldenström macroglobulinemia.
Waldenström macroglobulinemia is a lymphoplasmacytic lymphoma. A serum monoclonal IgM protein is required to establish this diagnosis. The clinical features patients develop include normochromic normocytic anemia, thrombocytopenia, hepatosplenomegaly, lymphadenopathy and signs of hyperviscosity. The International Staging System for Waldenström macroglobulinemia divides patients prognostically ...
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ژورنال
عنوان ژورنال: Internal Medicine
سال: 2004
ISSN: 0918-2918,1349-7235
DOI: 10.2169/internalmedicine.43.766